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Predictive model created for AMD, according to researchers

A formula created by researchers at Tufts Medical Center will predict how likely it is for individuals with certain genetic profiles and lifestyle behaviors to develop advanced age-related macular degeneration (AMD).

Six genotypes that either increase or decrease the risk for AMD were evaluated. Age, sex, and education as well as smoking status and higher body mass index were incorporated, which increase risk of AMD, and supplemented with a high-dose formulation of antioxidants and zinc, which delays progression of the disease.

Johanna M. Seddon, MD, ScM, professor of ophthalmology, Tufts University School of Medicine, and her colleagues, using their new algorithm determined that several genotypes plus the lifestyle factors could predict progression to the advanced forms of AMD with a certainty as high as 83%.

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